ABSTRACT
Background: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy. Prophylactic oral iron is recommended during pregnancy to meet the increased requirement of iron. In India, more than 50% women become pregnant with low baseline haemoglobin level resulting in high incidence of moderate to severe anaemia in pregnancy where oral iron therapy cannot meet the requirement. This study was undertaken for critical evaluation of iron sucrose in terms of efficacy, safety, and feasibility along with any reduction in blood transfusion rate. Aims & Objective: To evaluate the efficacy of intravenous Iron sucrose in antenatal patients with Iron deficiency anaemia and to study the side effects of intra venous Iron sucrose. Material and Methods: This prospective study was conducted from Nov 2012 to June 2013 at VS General Hospital, Ahmedabad. 60 antenatal patients found to have anaemia having Hb level < 9 gm% were admitted and given intravenous iron sucrose therapy 100mg alternate day after calculating the dose of the iron requirement. Results: In patients having moderate anaemia (Hb 7-9 gm%), the rise in Hb found to be 2.17 ± 0.45 gm% from pre-treatment Hb of 7.88 ± 0.58 gm% to 9.9 ± 0.53 gm%. In patients with severe anaemia (Hb < 7 gm%), the rise in Hb was observed up to 2.73 ± 0.51 (SD) gm% after 1 month of iron sucrose treatment. No major side effects or anaphylactic reactions were noted during the study period. Conclusion: Parenterally administered iron sucrose elevates Hb and restores iron stores earlier and also that intravenous iron administration has led to the reduction in the rate of blood transfusion rate.
ABSTRACT
Background: With all the modern needs of contraception rising on one side, infertility is still a major challenge to the gynaecological practitioners on other hand. Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility, being found in ∼75% of cases. PCOS now proves to be a significant factor in female infertility with prevalence of 0.6 to 3.4% in infertile couples. With improving laboratory facilities, sonography and with routine laparoscopic evaluation of infertility, PCOS has shown a remarkable increase of incidence in recent years. Aims & Objective: The diagnosis of PCOS by ultrasonography & investigations like LH, FSH, Prolactin and or Laparoscopy. The evaluation of treatment options like clomiphene citrate, metformin and laparoscopic ovarian drilling. Material and Methods: This is a study of 100 cases of infertility with polycystic ovarian syndrome and its pregnancy outcome. In this study from May 2011 to April 2013,100 cases of Infertility with PCOS were studied at the tertiary care center. Hormonal assay, Ultrasound and laparoscopy were used for diagnosis. Clomiphene citrate, metformin and laparoscopic ovarian drilling were used as treatment modalities. Results: In our study 58% patients were in the age group of 21-25 years and 100% patients complained of infertility among which 60% were of primary type. LH:FSH ratio was more than 1.6 in nearly 82% patients. Among all treatment modalities conception rate with Clomiphene citrate was 40%, with metformin it was 20% and with laparoscopic ovarian drilling followed by C/C it was 65%. Conclusion: PCOS is emerging disease of the new generation found more in young adults being the leading cause of infertility. Apart from diet and exercise changes in lifestyle modification treatment is required in most patients with good conception rate with C/C and laparoscopic ovarian drilling.